Fetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice

Fetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice

•Aberrant exposures to glucocorticoids during fetal life programme the risk of psychiatric disease in offspring.•Placental 11β-HSD2 protects the fetus from maternal glucocorticoids.•This study investigates the role of 11β-HSD2 in the fetal brain.•Deletion of 11β-HSD2 in the fetal brain causes depres...

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Bibliographic Details
Main Authors: Wyrwoll, Caitlin, Keith, Marianne, Noble, June, Stevenson, Paula L., Bombail, Vincent, Crombie, Sandra, Evans, Louise C., Bailey, Matthew A., Wood, Emma, Seckl, Jonathan R., Holmes, Megan C.
Format: Online
Language:English
Published: Pergamon Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510145/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510145/

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