Prenatal Excess Glucocorticoid Exposure and Adult Affective Disorders: A Role for Serotonergic and Catecholamine Pathways

Fetal glucocorticoid exposure is a key mechanism proposed to underlie prenatal ‘programming’ of adult affective behaviours such as depression and anxiety. Indeed, the glucocorticoid metabolising enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which is highly expressed in the placenta and...

Full description

Bibliographic Details
Main Authors: Wyrwoll, Caitlin S., Holmes, Megan C.
Format: Online
Language:English
Published: S. Karger AG 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388616/