A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mat...

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Main Authors:	Dua, P, Hawkins, E, van der Graaf, PH
Format:	Online
Language:	English
Published:	John Wiley & Sons, Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505827/

id	pubmed-4505827
recordtype	oai_dc
spelling	pubmed-45058272015-07-22 A Tutorial on Target-Mediated Drug Disposition (TMDD) Models Dua, P Hawkins, E van der Graaf, PH Tutorial Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials. John Wiley & Sons, Ltd 2015-06 2015-06-15 /pmc/articles/PMC4505827/ /pubmed/26225261 http://dx.doi.org/10.1002/psp4.41 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dua, P Hawkins, E van der Graaf, PH
spellingShingle	Dua, P Hawkins, E van der Graaf, PH A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
author_facet	Dua, P Hawkins, E van der Graaf, PH
author_sort	Dua, P
title	A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_short	A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_full	A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_fullStr	A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_full_unstemmed	A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
title_sort	tutorial on target-mediated drug disposition (tmdd) models
description	Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials.
publisher	John Wiley & Sons, Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505827/
_version_	1613248943174451200

A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

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