A Tutorial on Target-Mediated Drug Disposition (TMDD) Models

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mat...

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Bibliographic Details
Main Authors: Dua, P, Hawkins, E, van der Graaf, PH
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505827/