Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency

Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency

Type 2 diabetes mellitus (T2DM) is a pervasive metabolic syndrome that is characterized by insulin resistance, hyperglycemia and dyslipidemia. As full agonists of PPARγ, thiazolidinedione (TZD) drugs elicit antidiabetic effects by targeting PPARγ but is accompanied by weight gain, fluid retention an...

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Bibliographic Details
Main Authors: Zheng, Weili, Qiu, Lin, Wang, Rui, Feng, Xuhui, Han, Yaping, Zhu, Yanlin, Chen, Dezhou, Liu, Yijie, Jin, Lihua, Li, Yong
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505335/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505335/

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