Total Synthesis of the Antimitotic Marine Macrolide (−)-Leiodermatolide**
Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer drug discovery. In pursuit of a sustainable supply, we report a highly stereocontrolled total synthesis...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
WILEY-VCH Verlag
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499261/ |