The proliferation rate paradox in antimitotic chemotherapy

Cytotoxic cancer chemotherapy drugs are believed to gain selectivity by targeting cells that proliferate rapidly. However, the proliferation rate is low in many chemosensitive human cancers, and it is not clear how a drug that only kills dividing cells could promote tumor regression. Four potential...

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Bibliographic Details
Main Author: Mitchison, Timothy J.
Format: Online
Language:English
Published: The American Society for Cell Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248889/