From bacterial to human dihydrouridine synthase: automated structure determination

From bacterial to human dihydrouridine synthase: automated structure determination

The crystal structure of a human dihydrouridine synthase, an enzyme associated with lung cancer, with 18% sequence identity to a T. maritima enzyme, has been determined at 1.9 Å resolution by molecular replacement after extensive molecular remodelling of the template.

Bibliographic Details
Main Authors: Whelan, Fiona, Jenkins, Huw T., Griffiths, Samuel C., Byrne, Robert T., Dodson, Eleanor J., Antson, Alfred A.
Format: Online
Language:English
Published: International Union of Crystallography 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498606/
id pubmed-4498606
recordtype oai_dc
spelling pubmed-44986062015-07-14 From bacterial to human dihydrouridine synthase: automated structure determination Whelan, Fiona Jenkins, Huw T. Griffiths, Samuel C. Byrne, Robert T. Dodson, Eleanor J. Antson, Alfred A. Research Papers The crystal structure of a human dihydrouridine synthase, an enzyme associated with lung cancer, with 18% sequence identity to a T. maritima enzyme, has been determined at 1.9 Å resolution by molecular replacement after extensive molecular remodelling of the template. International Union of Crystallography 2015-06-30 /pmc/articles/PMC4498606/ /pubmed/26143927 http://dx.doi.org/10.1107/S1399004715009220 Text en © Whelan et al. 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Whelan, Fiona
Jenkins, Huw T.
Griffiths, Samuel C.
Byrne, Robert T.
Dodson, Eleanor J.
Antson, Alfred A.
spellingShingle Whelan, Fiona
Jenkins, Huw T.
Griffiths, Samuel C.
Byrne, Robert T.
Dodson, Eleanor J.
Antson, Alfred A.
From bacterial to human dihydrouridine synthase: automated structure determination
author_facet Whelan, Fiona
Jenkins, Huw T.
Griffiths, Samuel C.
Byrne, Robert T.
Dodson, Eleanor J.
Antson, Alfred A.
author_sort Whelan, Fiona
title From bacterial to human dihydrouridine synthase: automated structure determination
title_short From bacterial to human dihydrouridine synthase: automated structure determination
title_full From bacterial to human dihydrouridine synthase: automated structure determination
title_fullStr From bacterial to human dihydrouridine synthase: automated structure determination
title_full_unstemmed From bacterial to human dihydrouridine synthase: automated structure determination
title_sort from bacterial to human dihydrouridine synthase: automated structure determination
description The crystal structure of a human dihydrouridine synthase, an enzyme associated with lung cancer, with 18% sequence identity to a T. maritima enzyme, has been determined at 1.9 Å resolution by molecular replacement after extensive molecular remodelling of the template.
publisher International Union of Crystallography
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498606/
_version_ 1613246506910875648

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