From bacterial to human dihydrouridine synthase: automated structure determination
The crystal structure of a human dihydrouridine synthase, an enzyme associated with lung cancer, with 18% sequence identity to a T. maritima enzyme, has been determined at 1.9 Å resolution by molecular replacement after extensive molecular remodelling of the template.
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
International Union of Crystallography
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498606/ |