HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

Many patients with hematological neoplasms fail to mobilize sufficient numbers of hematopoietic stem cells (HSCs) in response to granulocyte colony-stimulating factor (G-CSF) precluding subsequent autologous HSC transplantation. Plerixafor, a specific antagonist of the chemokine receptor CXCR4, can...

Full description

Bibliographic Details
Main Authors: Forristal, C E, Nowlan, B, Jacobsen, R N, Barbier, V, Walkinshaw, G, Walkley, C R, Winkler, I G, Levesque, J P
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498452/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498452/

Similar Items