Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

The rapid proliferation of myeloid leukemia cells is highly dependent on increased glucose metabolism. Through an unbiased metabolomics analysis of leukemia cells, we found that the glycogenic precursor UDP-D-glucose is pervasively upregulated, despite low glycogen levels. Targeting the rate-limitin...

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Bibliographic Details
Main Authors: Bhanot, Haymanti, Reddy, Mamatha M., Nonami, Atsushi, Weisberg, Ellen L., Bonal, Dennis, Kirschmeier, Paul T., Salgia, Sabrina, Podar, Klaus, Galinsky, Ilene, Chowdary, Tirumala K., Neuberg, Donna, Tonon, Giovanni, Stone, Richard M., Asara, John, Griffin, James D., Sattler, Martin
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497855/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497855/

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