Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies that currently has no effective therapy. We performed quantitative high-throughput screening (qHTS) in three ATC cell lines using 3,282 clinically approved drugs and drug candidates, and identified 100 active agents. Enrich...

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Bibliographic Details
Main Authors: Zhang, Lisa, Zhang, Yaqin, Mehta, Amit, Boufraqech, Myriem, Davis, Sean, Wang, Jing, Tian, Ze, Yu, Zhiya, Boxer, Matthew B., Kiefer, Jeffrey A., Copland, John A., Smallridge, Robert C., Li, Zhuyin, Shen, Min, Kebebew, Electron
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496203/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496203/

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