WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization induced by ultraviolet light C (UVC) or the ca...

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Bibliographic Details
Main Authors: Tomas, Alejandra, Vaughan, Simon O., Burgoyne, Thomas, Sorkin, Alexander, Hartley, John A., Hochhauser, Daniel, Futter, Clare E.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490399/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490399/

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