2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins

Nontoxic naturally occurring metabolite of estrogen namely 2-methoxyestradial (2ME2) found in serum and urine has been shown to be antitumorigenic in various tumor models including the prostate. A recent study conducted in breast cancer cells showed growth stimulatory effect of 2ME2 when used at low...

Full description

Bibliographic Details
Main Authors:	Horny, Cara, Balasubashini, Muralimanoharan Sri, Komanduri, Krishna, Ganapathy, Manonmani, Yeh, I-Tien, Ghosh, Rita, Kumar, Addanki P.
Format:	Online
Language:	English
Published:	Libertas Academica 2009
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474335/

id	pubmed-4474335
recordtype	oai_dc
spelling	pubmed-44743352015-06-29 2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins Horny, Cara Balasubashini, Muralimanoharan Sri Komanduri, Krishna Ganapathy, Manonmani Yeh, I-Tien Ghosh, Rita Kumar, Addanki P. Short Report Nontoxic naturally occurring metabolite of estrogen namely 2-methoxyestradial (2ME2) found in serum and urine has been shown to be antitumorigenic in various tumor models including the prostate. A recent study conducted in breast cancer cells showed growth stimulatory effect of 2ME2 when used at low concentrations (10–750 nM). Studies from our laboratory has demonstrated prostate tumor preventive ability of 50 mg/kg 2-ME2. In this study we show that concentrations of 2-ME2 as low as 1 µM is sufficient to inhibit proliferation and induce apoptosis in androgen responsive LNCaP cells. In addition oral administration of doses lower than 50 mg/kg prevented prostate tumor development in LNCaP xenograft model. The observed tumor growth inhibition was associated with induction of apoptosis, increased expression of Wee1 kinase and p34cdc2. In addition administration of 25 mg/kg 2-ME2 prevented tumor development significantly that is associated with reduction in serum PSA levels. Libertas Academica 2009-06-16 /pmc/articles/PMC4474335/ /pubmed/26124676 Text en © 2009 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Horny, Cara Balasubashini, Muralimanoharan Sri Komanduri, Krishna Ganapathy, Manonmani Yeh, I-Tien Ghosh, Rita Kumar, Addanki P.
spellingShingle	Horny, Cara Balasubashini, Muralimanoharan Sri Komanduri, Krishna Ganapathy, Manonmani Yeh, I-Tien Ghosh, Rita Kumar, Addanki P. 2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins
author_facet	Horny, Cara Balasubashini, Muralimanoharan Sri Komanduri, Krishna Ganapathy, Manonmani Yeh, I-Tien Ghosh, Rita Kumar, Addanki P.
author_sort	Horny, Cara
title	2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins
title_short	2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins
title_full	2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins
title_fullStr	2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins
title_full_unstemmed	2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins
title_sort	2-methoxyestradiol prevents lncap tumor development in nude mice: potential role of g2/m regulatory proteins
description	Nontoxic naturally occurring metabolite of estrogen namely 2-methoxyestradial (2ME2) found in serum and urine has been shown to be antitumorigenic in various tumor models including the prostate. A recent study conducted in breast cancer cells showed growth stimulatory effect of 2ME2 when used at low concentrations (10–750 nM). Studies from our laboratory has demonstrated prostate tumor preventive ability of 50 mg/kg 2-ME2. In this study we show that concentrations of 2-ME2 as low as 1 µM is sufficient to inhibit proliferation and induce apoptosis in androgen responsive LNCaP cells. In addition oral administration of doses lower than 50 mg/kg prevented prostate tumor development in LNCaP xenograft model. The observed tumor growth inhibition was associated with induction of apoptosis, increased expression of Wee1 kinase and p34cdc2. In addition administration of 25 mg/kg 2-ME2 prevented tumor development significantly that is associated with reduction in serum PSA levels.
publisher	Libertas Academica
publishDate	2009
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474335/
_version_	1613237893787025408

2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins

Similar Items