Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection

Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection

Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promotes tissue damage. Conversely, mechanisms that constrain neutrophil serine protease activity protect against tissue damage but may have the untoward e...

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Bibliographic Details
Main Authors: Zhao, Yani, Olonisakin, Tolani F., Xiong, Zeyu, Hulver, Mei, Sayeed, Sameera, Yu, Min Ting, Gregory, Alyssa D., Kochman, Elizabeth J., Chen, Bill B., Mallampalli, Rama K., Sun, Ming, Silverstein, Roy L., Stolz, Donna B., Shapiro, Steve D., Ray, Anuradha, Ray, Prabir, Lee, Janet S.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465063/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465063/

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