Piezo1 links mechanical forces to red blood cell volume

Red blood cells (RBCs) experience significant mechanical forces while recirculating, but the consequences of these forces are not fully understood. Recent work has shown that gain-of-function mutations in mechanically activated Piezo1 cation channels are associated with the dehydrating RBC disease x...

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Bibliographic Details
Main Authors: Cahalan, Stuart M, Lukacs, Viktor, Ranade, Sanjeev S, Chien, Shu, Bandell, Michael, Patapoutian, Ardem
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456639/