Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer

Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer

Our previous studies demonstrated that specific inhibition of the BIG3-PHB2 complex, which is a critical modulator in estrogen (E2) signaling, using ERAP, a dominant negative peptide inhibitor, leads to suppression of E2-dependent estrogen receptor (ER) alpha activation through the reactivation of t...

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Bibliographic Details
Main Authors: Yoshimaru, Tetsuro, Komatsu, Masato, Miyoshi, Yasuo, Honda, Junko, Sasa, Mitsunori, Katagiri, Toyomasa
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452155/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452155/

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