Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway

Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway

Matrix stiffness potently regulates cellular behavior in various biological contexts. In breast tumours, the presence of dense clusters of collagen fibrils indicates increased matrix stiffness and correlates with poor survival. It is unclear how mechanical inputs are transduced into transcriptional...

Full description

Bibliographic Details
Main Authors: Wei, Spencer C., Fattet, Laurent, Tsai, Jeff H., Guo, Yurong, Pai, Vincent H., Majeski, Hannah E., Chen, Albert C., Sah, Robert L., Taylor, Susan S., Engler, Adam J., Yang, Jing
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452027/

Similar Items

Similar Items