Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
Mansouri et al. applied targeted deep sequencing to identify mutations within NF-κB core complex genes in CLL. NFKBIE, the gene encoding the inhibitory IκBε molecule, was most frequently mutated, especially in poor-prognostic subgroups of CLL. The authors show that NFKBIE mutations were associated w...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451125/ |
| id |
pubmed-4451125 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-44511252015-12-01 Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia Mansouri, Larry Sutton, Lesley-Ann Ljungström, Viktor Bondza, Sina Arngården, Linda Bhoi, Sujata Larsson, Jimmy Cortese, Diego Kalushkova, Antonia Plevova, Karla Young, Emma Gunnarsson, Rebeqa Falk-Sörqvist, Elin Lönn, Peter Muggen, Alice F. Yan, Xiao-Jie Sander, Birgitta Enblad, Gunilla Smedby, Karin E. Juliusson, Gunnar Belessi, Chrysoula Rung, Johan Chiorazzi, Nicholas Strefford, Jonathan C. Langerak, Anton W. Pospisilova, Sarka Davi, Frederic Hellström, Mats Jernberg-Wiklund, Helena Ghia, Paolo Söderberg, Ola Stamatopoulos, Kostas Nilsson, Mats Rosenquist, Richard Brief Definitive Report Mansouri et al. applied targeted deep sequencing to identify mutations within NF-κB core complex genes in CLL. NFKBIE, the gene encoding the inhibitory IκBε molecule, was most frequently mutated, especially in poor-prognostic subgroups of CLL. The authors show that NFKBIE mutations were associated with significantly reduced IkBε expression and p65 inhibition, ultimately leading to NF-κB activation and a more aggressive disease. The Rockefeller University Press 2015-06-01 /pmc/articles/PMC4451125/ /pubmed/25987724 http://dx.doi.org/10.1084/jem.20142009 Text en © 2015 Mansouri et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mansouri, Larry Sutton, Lesley-Ann Ljungström, Viktor Bondza, Sina Arngården, Linda Bhoi, Sujata Larsson, Jimmy Cortese, Diego Kalushkova, Antonia Plevova, Karla Young, Emma Gunnarsson, Rebeqa Falk-Sörqvist, Elin Lönn, Peter Muggen, Alice F. Yan, Xiao-Jie Sander, Birgitta Enblad, Gunilla Smedby, Karin E. Juliusson, Gunnar Belessi, Chrysoula Rung, Johan Chiorazzi, Nicholas Strefford, Jonathan C. Langerak, Anton W. Pospisilova, Sarka Davi, Frederic Hellström, Mats Jernberg-Wiklund, Helena Ghia, Paolo Söderberg, Ola Stamatopoulos, Kostas Nilsson, Mats Rosenquist, Richard |
| spellingShingle |
Mansouri, Larry Sutton, Lesley-Ann Ljungström, Viktor Bondza, Sina Arngården, Linda Bhoi, Sujata Larsson, Jimmy Cortese, Diego Kalushkova, Antonia Plevova, Karla Young, Emma Gunnarsson, Rebeqa Falk-Sörqvist, Elin Lönn, Peter Muggen, Alice F. Yan, Xiao-Jie Sander, Birgitta Enblad, Gunilla Smedby, Karin E. Juliusson, Gunnar Belessi, Chrysoula Rung, Johan Chiorazzi, Nicholas Strefford, Jonathan C. Langerak, Anton W. Pospisilova, Sarka Davi, Frederic Hellström, Mats Jernberg-Wiklund, Helena Ghia, Paolo Söderberg, Ola Stamatopoulos, Kostas Nilsson, Mats Rosenquist, Richard Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia |
| author_facet |
Mansouri, Larry Sutton, Lesley-Ann Ljungström, Viktor Bondza, Sina Arngården, Linda Bhoi, Sujata Larsson, Jimmy Cortese, Diego Kalushkova, Antonia Plevova, Karla Young, Emma Gunnarsson, Rebeqa Falk-Sörqvist, Elin Lönn, Peter Muggen, Alice F. Yan, Xiao-Jie Sander, Birgitta Enblad, Gunilla Smedby, Karin E. Juliusson, Gunnar Belessi, Chrysoula Rung, Johan Chiorazzi, Nicholas Strefford, Jonathan C. Langerak, Anton W. Pospisilova, Sarka Davi, Frederic Hellström, Mats Jernberg-Wiklund, Helena Ghia, Paolo Söderberg, Ola Stamatopoulos, Kostas Nilsson, Mats Rosenquist, Richard |
| author_sort |
Mansouri, Larry |
| title |
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia |
| title_short |
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia |
| title_full |
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia |
| title_fullStr |
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia |
| title_full_unstemmed |
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia |
| title_sort |
functional loss of iκbε leads to nf-κb deregulation in aggressive chronic lymphocytic leukemia |
| description |
Mansouri et al. applied targeted deep sequencing to identify mutations within NF-κB core complex genes in CLL. NFKBIE, the gene encoding the inhibitory IκBε molecule, was most frequently mutated, especially in poor-prognostic subgroups of CLL. The authors show that NFKBIE mutations were associated with significantly reduced IkBε expression and p65 inhibition, ultimately leading to NF-κB activation and a more aggressive disease. |
| publisher |
The Rockefeller University Press |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451125/ |
| _version_ |
1613230205978017792 |