Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Mansouri et al. applied targeted deep sequencing to identify mutations within NF-κB core complex genes in CLL. NFKBIE, the gene encoding the inhibitory IκBε molecule, was most frequently mutated, especially in poor-prognostic subgroups of CLL. The authors show that NFKBIE mutations were associated w...

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Bibliographic Details
Main Authors: Mansouri, Larry, Sutton, Lesley-Ann, Ljungström, Viktor, Bondza, Sina, Arngården, Linda, Bhoi, Sujata, Larsson, Jimmy, Cortese, Diego, Kalushkova, Antonia, Plevova, Karla, Young, Emma, Gunnarsson, Rebeqa, Falk-Sörqvist, Elin, Lönn, Peter, Muggen, Alice F., Yan, Xiao-Jie, Sander, Birgitta, Enblad, Gunilla, Smedby, Karin E., Juliusson, Gunnar, Belessi, Chrysoula, Rung, Johan, Chiorazzi, Nicholas, Strefford, Jonathan C., Langerak, Anton W., Pospisilova, Sarka, Davi, Frederic, Hellström, Mats, Jernberg-Wiklund, Helena, Ghia, Paolo, Söderberg, Ola, Stamatopoulos, Kostas, Nilsson, Mats, Rosenquist, Richard
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451125/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451125/

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