Argonaute of the archaeon Pyrococcus furiosus is a DNA-guided nuclease that targets cognate DNA

Functions of prokaryotic Argonautes (pAgo) have long remained elusive. Recently, Argonautes of the bacteria Rhodobacter sphaeroides and Thermus thermophilus were demonstrated to be involved in host defense. The Argonaute of the archaeon Pyrococcus furiosus (PfAgo) belongs to a different branch in th...

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Bibliographic Details
Main Authors: Swarts, Daan C., Hegge, Jorrit W., Hinojo, Ismael, Shiimori, Masami, Ellis, Michael A., Dumrongkulraksa, Justin, Terns, Rebecca M., Terns, Michael P., van der Oost, John
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446448/