Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus

•Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s.•Combined surveillance data and whole-genome sequencing analysis dissected changes in the epidemiology of MRSA.•Fusidic acid resistance emerged fastest in the community, where it was used the mo...

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Main Authors:	Ellington, Matthew J., Reuter, Sandra, Harris, Simon R., Holden, Matthew T.G., Cartwright, Edward J., Greaves, Daniel, Gerver, Sarah M., Hope, Russell, Brown, Nicholas M., Török, M. Estee, Parkhill, Julian, Köser, Claudio U., Peacock, Sharon J.
Format:	Online
Language:	English
Published:	Elsevier Science Publishers 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415905/

id	pubmed-4415905
recordtype	oai_dc
spelling	pubmed-44159052015-05-04 Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus Ellington, Matthew J. Reuter, Sandra Harris, Simon R. Holden, Matthew T.G. Cartwright, Edward J. Greaves, Daniel Gerver, Sarah M. Hope, Russell Brown, Nicholas M. Török, M. Estee Parkhill, Julian Köser, Claudio U. Peacock, Sharon J. Article •Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s.•Combined surveillance data and whole-genome sequencing analysis dissected changes in the epidemiology of MRSA.•Fusidic acid resistance emerged fastest in the community, where it was used the most.•Resistance occurred in diverse MRSA strains, encoded on staphylococcal cassette chromosome (SCC) elements.•Compact chimeric dual-resistance cassettes indicate a new mechanism for resistance accrual in MRSA. Elsevier Science Publishers 2015-05 /pmc/articles/PMC4415905/ /pubmed/25769787 http://dx.doi.org/10.1016/j.ijantimicag.2015.01.009 Text en © 2015 Matthew J. Ellington http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ellington, Matthew J. Reuter, Sandra Harris, Simon R. Holden, Matthew T.G. Cartwright, Edward J. Greaves, Daniel Gerver, Sarah M. Hope, Russell Brown, Nicholas M. Török, M. Estee Parkhill, Julian Köser, Claudio U. Peacock, Sharon J.
spellingShingle	Ellington, Matthew J. Reuter, Sandra Harris, Simon R. Holden, Matthew T.G. Cartwright, Edward J. Greaves, Daniel Gerver, Sarah M. Hope, Russell Brown, Nicholas M. Török, M. Estee Parkhill, Julian Köser, Claudio U. Peacock, Sharon J. Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
author_facet	Ellington, Matthew J. Reuter, Sandra Harris, Simon R. Holden, Matthew T.G. Cartwright, Edward J. Greaves, Daniel Gerver, Sarah M. Hope, Russell Brown, Nicholas M. Török, M. Estee Parkhill, Julian Köser, Claudio U. Peacock, Sharon J.
author_sort	Ellington, Matthew J.
title	Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
title_short	Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
title_full	Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
title_fullStr	Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
title_full_unstemmed	Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus
title_sort	emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant staphylococcus aureus
description	•Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s.•Combined surveillance data and whole-genome sequencing analysis dissected changes in the epidemiology of MRSA.•Fusidic acid resistance emerged fastest in the community, where it was used the most.•Resistance occurred in diverse MRSA strains, encoded on staphylococcal cassette chromosome (SCC) elements.•Compact chimeric dual-resistance cassettes indicate a new mechanism for resistance accrual in MRSA.
publisher	Elsevier Science Publishers
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415905/
_version_	1613217968629481472

Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus

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