PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

The protein phosphatase 2A (PP2A) is a key tumor suppressor which has emerged as a novel molecular target in some human cancers. Here, we show that PP2A inhibition is a common event in breast cancer and identified PP2A phosphorylation and deregulation SET and CIP2A as molecular contributing mechanis...

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Bibliographic Details
Main Authors: Rincón, Raúl, Cristóbal, Ion, Zazo, Sandra, Arpí, Oriol, Menéndez, Silvia, Manso, Rebeca, Lluch, Ana, Eroles, Pilar, Rovira, Ana, Albanell, Joan, García-Foncillas, Jesús, Madoz-Gúrpide, Juan, Rojo, Federico
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414191/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414191/

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