The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse

Osteosarcomas remain an enigmatic group of malignancies that share in common the presence of transformed cells producing osteoid matrix, even if these cells comprise a minority of the tumor volume. The differentiation state of osteosarcomas has therefore become a topic of interest and challenge to t...

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Bibliographic Details
Main Authors: Quist, Tyler, Jin, Huifeng, Zhu, Ju-Fen, Smith-Fry, Kyllie, Capecchi, Mario R., Jones, Kevin B.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411188/