The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis

Synovial sarcomas are aggressive soft-tissue malignancies that express chromosomal translocation-generated fusion genes, SS18-SSX1 or SS18-SSX2 in most cases. Here, we report a mouse sarcoma model expressing SS18-SSX1, complementing our prior model expressing SS18-SSX2. Exome sequencing identified n...

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Bibliographic Details
Main Authors: Jones, Kevin B., Barrott, Jared J., Xie, Mingchao, Haldar, Malay, Jin, Huifeng, Zhu, Ju-Fen, Monument, Michael J., Mosbruger, Tim L., Langer, Ellen M., Randall, R. Lor, Wilson, Richard K., Cairns, Bradley R., Ding, Li, Capecchi, Mario R.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014712/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014712/

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