Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease

Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease

The SLX1-SLX4 endonuclease required for homologous recombination and DNA repair in eukaryotic cells cleaves a variety of branched DNA structures. The nuclease subunit SLX1 is activated by association with a scaffolding protein SLX4. At the present time, little is known about the structure of SLX1-SL...

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Bibliographic Details
Main Authors: Gaur, Vineet, Wyatt, Haley D.M., Komorowska, Weronika, Szczepanowski, Roman H., de Sanctis, Daniele, Gorecka, Karolina M., West, Stephen C., Nowotny, Marcin
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407285/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407285/

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