FBXW7 modulates cellular stress response and metastatic potential via HSF1 post-translational modification

FBXW7 modulates cellular stress response and metastatic potential via HSF1 post-translational modification

Heat-shock factor 1 (HSF1) orchestrates the heat-shock response in eukaryotes. Although this pathway has been evolved to help cells adapt in the presence of challenging conditions, it is co-opted in cancer to support malignancy. However, the mechanisms that regulate HSF1 and thus cellular stress res...

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Bibliographic Details
Main Authors: Kourtis, Nikos, Moubarak, Rana S., Aranda-Orgilles, Beatriz, Lui, Kevin, Aydin, Iraz T., Trimarchi, Thomas, Darvishian, Farbod, Salvaggio, Christine, Zhong, Judy, Bhatt, Kamala, Chen, Emily I., Celebi, Julide T., Lazaris, Charalampos, Tsirigos, Aristotelis, Osman, Iman, Hernando, Eva, Aifantis, Iannis
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401662/

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