Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice
High glucocorticoid levels induced by stress enhance the memory of fearful events and may contribute to the development of anxiety and posttraumatic stress disorder. In contrast, elevated glucocorticoids associated with ageing impair spatial memory. We have previously shown that pharmacological inhi...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Pergamon Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389269/ |