Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non-homologous end-joining (cNHEJ). Support of cNHEJ i...

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Bibliographic Details
Main Authors: Cook, Rebecca, Zoumpoulidou, Georgia, Luczynski, Maciej T., Rieger, Simone, Moquet, Jayne, Spanswick, Victoria J., Hartley, John A., Rothkamm, Kai, Huang, Paul H., Mittnacht, Sibylle
Format: Online
Language:English
Published: Cell Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386026/

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