Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts

Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts

Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimag...

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Main Authors: Oertel-Knöchel, Viola, Lancaster, Thomas M., Knöchel, Christian, Stäblein, Michael, Storchak, Helena, Reinke, Britta, Jurcoane, Alina, Kniep, Jonathan, Prvulovic, David, Mantripragada, Kiran, Tansey, Katherine E., O’Donovan, Michael C., Owen, Michael J., Linden, David E.J.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375641/
id pubmed-4375641
recordtype oai_dc
spelling pubmed-43756412015-04-03 Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts Oertel-Knöchel, Viola Lancaster, Thomas M. Knöchel, Christian Stäblein, Michael Storchak, Helena Reinke, Britta Jurcoane, Alina Kniep, Jonathan Prvulovic, David Mantripragada, Kiran Tansey, Katherine E. O’Donovan, Michael C. Owen, Michael J. Linden, David E.J. Regular Article Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimaging has developed into a powerful tool of translational neuroscience. In this study, we used genome wide significant SZ risk variants to test the predictive capacity of the polygenic model and explored potential associations with white matter volume, a key candidate in imaging phenotype for psychotic disorders. Elsevier 2015-03-13 /pmc/articles/PMC4375641/ /pubmed/25844328 http://dx.doi.org/10.1016/j.nicl.2015.03.005 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Oertel-Knöchel, Viola
Lancaster, Thomas M.
Knöchel, Christian
Stäblein, Michael
Storchak, Helena
Reinke, Britta
Jurcoane, Alina
Kniep, Jonathan
Prvulovic, David
Mantripragada, Kiran
Tansey, Katherine E.
O’Donovan, Michael C.
Owen, Michael J.
Linden, David E.J.
spellingShingle Oertel-Knöchel, Viola
Lancaster, Thomas M.
Knöchel, Christian
Stäblein, Michael
Storchak, Helena
Reinke, Britta
Jurcoane, Alina
Kniep, Jonathan
Prvulovic, David
Mantripragada, Kiran
Tansey, Katherine E.
O’Donovan, Michael C.
Owen, Michael J.
Linden, David E.J.
Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts
author_facet Oertel-Knöchel, Viola
Lancaster, Thomas M.
Knöchel, Christian
Stäblein, Michael
Storchak, Helena
Reinke, Britta
Jurcoane, Alina
Kniep, Jonathan
Prvulovic, David
Mantripragada, Kiran
Tansey, Katherine E.
O’Donovan, Michael C.
Owen, Michael J.
Linden, David E.J.
author_sort Oertel-Knöchel, Viola
title Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts
title_short Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts
title_full Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts
title_fullStr Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts
title_full_unstemmed Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts
title_sort schizophrenia risk variants modulate white matter volume across the psychosis spectrum: evidence from two independent cohorts
description Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effects of these variants, although polygenic neuroimaging has developed into a powerful tool of translational neuroscience. In this study, we used genome wide significant SZ risk variants to test the predictive capacity of the polygenic model and explored potential associations with white matter volume, a key candidate in imaging phenotype for psychotic disorders.
publisher Elsevier
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375641/
_version_ 1613204092747776000

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