Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape

Dendritic cells (DCs) and macrophages (Møs) internalize and process exogenous HIV-derived antigens for cross-presentation by MHC-I to cytotoxic CD8+ T cells (CTL). However, how degradation patterns of HIV antigens in the cross-presentation pathways affect immunodominance and immune escape is poorly...

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Bibliographic Details
Main Authors: Dinter, Jens, Duong, Ellen, Lai, Nicole Y., Berberich, Matthew J., Kourjian, Georgio, Bracho-Sanchez, Edith, Chu, Duong, Su, Hang, Zhang, Shao Chong, Le Gall, Sylvie
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364612/

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