CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans

CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans

In this study, Santos Susin and colleagues demonstrate that a serum-stable CD47 agonist peptide is highly effective at inducing apoptosis in chronic lymphocytic leukemia B-cells and mice.

Bibliographic Details
Main Authors: Martinez-Torres, Ana-Carolina, Quiney, Claire, Attout, Tarik, Boullet, Heloïse, Herbi, Linda, Vela, Laura, Barbier, Sandrine, Chateau, Danielle, Chapiro, Elise, Nguyen-Khac, Florence, Davi, Frédéric, Le Garff-Tavernier, Magali, Moumné, Roba, Sarfati, Marika, Karoyan, Philippe, Merle-Béral, Hélène, Launay, Pierre, Susin, Santos A.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348493/
id pubmed-4348493
recordtype oai_dc
spelling pubmed-43484932015-03-06 CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans Martinez-Torres, Ana-Carolina Quiney, Claire Attout, Tarik Boullet, Heloïse Herbi, Linda Vela, Laura Barbier, Sandrine Chateau, Danielle Chapiro, Elise Nguyen-Khac, Florence Davi, Frédéric Le Garff-Tavernier, Magali Moumné, Roba Sarfati, Marika Karoyan, Philippe Merle-Béral, Hélène Launay, Pierre Susin, Santos A. Research Article In this study, Santos Susin and colleagues demonstrate that a serum-stable CD47 agonist peptide is highly effective at inducing apoptosis in chronic lymphocytic leukemia B-cells and mice. Public Library of Science 2015-03-03 /pmc/articles/PMC4348493/ /pubmed/25734483 http://dx.doi.org/10.1371/journal.pmed.1001796 Text en © 2015 Martinez-Torres et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Martinez-Torres, Ana-Carolina
Quiney, Claire
Attout, Tarik
Boullet, Heloïse
Herbi, Linda
Vela, Laura
Barbier, Sandrine
Chateau, Danielle
Chapiro, Elise
Nguyen-Khac, Florence
Davi, Frédéric
Le Garff-Tavernier, Magali
Moumné, Roba
Sarfati, Marika
Karoyan, Philippe
Merle-Béral, Hélène
Launay, Pierre
Susin, Santos A.
spellingShingle Martinez-Torres, Ana-Carolina
Quiney, Claire
Attout, Tarik
Boullet, Heloïse
Herbi, Linda
Vela, Laura
Barbier, Sandrine
Chateau, Danielle
Chapiro, Elise
Nguyen-Khac, Florence
Davi, Frédéric
Le Garff-Tavernier, Magali
Moumné, Roba
Sarfati, Marika
Karoyan, Philippe
Merle-Béral, Hélène
Launay, Pierre
Susin, Santos A.
CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
author_facet Martinez-Torres, Ana-Carolina
Quiney, Claire
Attout, Tarik
Boullet, Heloïse
Herbi, Linda
Vela, Laura
Barbier, Sandrine
Chateau, Danielle
Chapiro, Elise
Nguyen-Khac, Florence
Davi, Frédéric
Le Garff-Tavernier, Magali
Moumné, Roba
Sarfati, Marika
Karoyan, Philippe
Merle-Béral, Hélène
Launay, Pierre
Susin, Santos A.
author_sort Martinez-Torres, Ana-Carolina
title CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
title_short CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
title_full CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
title_fullStr CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
title_full_unstemmed CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
title_sort cd47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia b cells via plcγ1 activation: evidence from mice and humans
description In this study, Santos Susin and colleagues demonstrate that a serum-stable CD47 agonist peptide is highly effective at inducing apoptosis in chronic lymphocytic leukemia B-cells and mice.
publisher Public Library of Science
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348493/
_version_ 1613194828618661888

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