Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage

Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We show that Ym1 and Ym2 induce neutrophil accumulation through expansion of interleukin 17 (IL-17)-producing γδ...

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Main Authors:	Sutherland, Tara E., Logan, Nicola, Rückerl, Dominik, Humbles, Alison A., Allan, Stuart M., Papayannopoulos, Venizelos, Stockinger, Brigitta, Maizels, Rick M., Allen, Judith E.
Format:	Online
Language:	English
Published:	2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338525/

id	pubmed-4338525
recordtype	oai_dc
spelling	pubmed-43385252015-06-01 Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage Sutherland, Tara E. Logan, Nicola Rückerl, Dominik Humbles, Alison A. Allan, Stuart M. Papayannopoulos, Venizelos Stockinger, Brigitta Maizels, Rick M. Allen, Judith E. Article Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We show that Ym1 and Ym2 induce neutrophil accumulation through expansion of interleukin 17 (IL-17)-producing γδ T cells. While BRP-39 did not influence neutrophilia, it was required for IL-17 production in γδ T cells, suggesting IL-17 regulation is an inherent feature of murine CLPs. Using a model of lung migrating nematode infection, we also found that IL-17 and neutrophilic inflammation induced by Ym1 limited parasite survival but at the cost of enhanced lung injury. These studies describe effector functions of CLPs consistent with innate host defense traits of the chitinase family. 2014-10-19 2014-12 /pmc/articles/PMC4338525/ /pubmed/25326751 http://dx.doi.org/10.1038/ni.3023 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sutherland, Tara E. Logan, Nicola Rückerl, Dominik Humbles, Alison A. Allan, Stuart M. Papayannopoulos, Venizelos Stockinger, Brigitta Maizels, Rick M. Allen, Judith E.
spellingShingle	Sutherland, Tara E. Logan, Nicola Rückerl, Dominik Humbles, Alison A. Allan, Stuart M. Papayannopoulos, Venizelos Stockinger, Brigitta Maizels, Rick M. Allen, Judith E. Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage
author_facet	Sutherland, Tara E. Logan, Nicola Rückerl, Dominik Humbles, Alison A. Allan, Stuart M. Papayannopoulos, Venizelos Stockinger, Brigitta Maizels, Rick M. Allen, Judith E.
author_sort	Sutherland, Tara E.
title	Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage
title_short	Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage
title_full	Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage
title_fullStr	Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage
title_full_unstemmed	Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage
title_sort	chitinase-like proteins promote il-17-mediated neutrophilia in a trade-off between nematode killing and host damage
description	Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We show that Ym1 and Ym2 induce neutrophil accumulation through expansion of interleukin 17 (IL-17)-producing γδ T cells. While BRP-39 did not influence neutrophilia, it was required for IL-17 production in γδ T cells, suggesting IL-17 regulation is an inherent feature of murine CLPs. Using a model of lung migrating nematode infection, we also found that IL-17 and neutrophilic inflammation induced by Ym1 limited parasite survival but at the cost of enhanced lung injury. These studies describe effector functions of CLPs consistent with innate host defense traits of the chitinase family.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338525/
_version_	1613191884930285568

Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage

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