Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage

Chitinase-like proteins promote IL-17-mediated neutrophilia in a trade-off between nematode killing and host damage

Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We show that Ym1 and Ym2 induce neutrophil accumulation through expansion of interleukin 17 (IL-17)-producing γδ...

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Bibliographic Details
Main Authors: Sutherland, Tara E., Logan, Nicola, Rückerl, Dominik, Humbles, Alison A., Allan, Stuart M., Papayannopoulos, Venizelos, Stockinger, Brigitta, Maizels, Rick M., Allen, Judith E.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338525/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338525/

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