Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like skin lesions and more severe allergen-induced dermatitis than wild-type mice. Mast cells were required for both AD models and remarkably increase...

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Bibliographic Details
Main Authors: Ando, Tomoaki, Xiao, Wenbin, Gao, Peisong, Namiranian, Siavash, Matsumoto, Kenji, Tomimori, Yoshiaki, Hong, Hong, Yamashita, Hirotaka, Kimura, Miho, Kashiwakura, Jun-ichi, Hata, Tissa R., Izuhara, Kenji, Gurish, Michael F., Roers, Axel, Rafaels, Nicholas M., Barnes, Kathleen C., Jamora, Colin, Kawakami, Yuko, Kawakami, Toshiaki
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329986/

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