Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration
Physiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space. Age-related macular degeneration (AMD) is associated with a breakdown of the subretinal immunosuppressive enviro...
Main Authors: | , , , , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
BlackWell Publishing Ltd
2015
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328649/ |