The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya

The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was as...

Full description

Bibliographic Details
Main Authors:	Ochola-Oyier, Lynette Isabella, Okombo, John, Mwai, Leah, Kiara, Steven M., Pole, Lewa, Tetteh, Kevin K. A., Nzila, Alexis, Marsh, Kevin
Format:	Online
Language:	English
Published:	American Society for Microbiology 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325780/

id	pubmed-4325780
recordtype	oai_dc
spelling	pubmed-43257802015-02-23 The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya Ochola-Oyier, Lynette Isabella Okombo, John Mwai, Leah Kiara, Steven M. Pole, Lewa Tetteh, Kevin K. A. Nzila, Alexis Marsh, Kevin Mechanisms of Resistance The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (P = 0.04). The high frequency of Pfmspdbl2 codon 591S in Kenya may be driven by the widespread use of lumefantrine in artemisinin combination therapy (Coartem). American Society for Microbiology 2015-02-11 2015-03 /pmc/articles/PMC4325780/ /pubmed/25534732 http://dx.doi.org/10.1128/AAC.03522-14 Text en Copyright © 2015, Ochola-Oyier et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ochola-Oyier, Lynette Isabella Okombo, John Mwai, Leah Kiara, Steven M. Pole, Lewa Tetteh, Kevin K. A. Nzila, Alexis Marsh, Kevin
spellingShingle	Ochola-Oyier, Lynette Isabella Okombo, John Mwai, Leah Kiara, Steven M. Pole, Lewa Tetteh, Kevin K. A. Nzila, Alexis Marsh, Kevin The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
author_facet	Ochola-Oyier, Lynette Isabella Okombo, John Mwai, Leah Kiara, Steven M. Pole, Lewa Tetteh, Kevin K. A. Nzila, Alexis Marsh, Kevin
author_sort	Ochola-Oyier, Lynette Isabella
title	The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
title_short	The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
title_full	The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
title_fullStr	The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
title_full_unstemmed	The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
title_sort	mspdbl2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in plasmodium falciparum isolates from kilifi, kenya
description	The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (P = 0.04). The high frequency of Pfmspdbl2 codon 591S in Kenya may be driven by the widespread use of lumefantrine in artemisinin combination therapy (Coartem).
publisher	American Society for Microbiology
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325780/
_version_	1613187219251527680

The MSPDBL2 Codon 591 Polymorphism Is Associated with Lumefantrine In Vitro Drug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya

Similar Items