Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation

Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation

To widen the therapeutic window for PET guided evaluation of novel anti-RA agents, modifications were made in a rat model of rheumatoid arthritis (RA). Arthritis was induced in the right knee of Wistar rats with repeated boosting to prolong articular inflammation. The contralateral knee served as co...

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Bibliographic Details
Main Authors: Chandrupatla, Durga M. S. H., Weijers, Karin, Gent, Yoony Y. J., de Greeuw, Inge, Lammertsma, Adriaan A., Jansen, Gerrit, van der Laken, Conny J., Molthoff, Carla F. M.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324741/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324741/

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