Diminished mTOR signaling: a common mode of action for endocrine longevity factors

Since the initial observation that a calorie-restricted (CR) diet can extend rodent lifespan, many genetic and pharmaceutical interventions that also extend lifespan in mammals have been discovered. The mechanism by which CR and these other interventions extend lifespan is the subject of significant...

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Bibliographic Details
Main Author: Lamming, Dudley W
Format: Online
Language:English
Published: Springer International Publishing 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320218/