Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1

Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1

Helicobacter pylori strains carrying the cagA gene are associated with severe disease outcomes, most notably gastric cancer. CagA protein is delivered into gastric epithelial cells by a type IV secretion system. The translocated CagA undergoes tyrosine phosphorylation at the C-terminal EPIYA motifs...

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Bibliographic Details
Main Authors: Hashi, Kana, Murata-Kamiya, Naoko, Varon, Christine, Mégraud, Francis, Dominguez-Bello, Maria Gloria, Hatakeyama, Masanori
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317943/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317943/

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