Reglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation
The ER quality control factor UDP-glucose:glycoprotein glucosyltransferase 1 modifies folding intermediates but most efficiently terminally misfolded targets. Whereas on-pathway targets are retained in the ER when trapped in monoglucosylated states, off-pathway proteins are degraded rapidly, exposin...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310732/ |