Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice

Interferon-alpha (IFN-α) is a proinflammatory cytokine that is widely used for the treatment of chronic viral hepatitis and malignancy, because of its immune-activating, antiviral, and antiproliferative properties. However, long-term IFN-α treatment frequently causes depression, which limits its cli...

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Bibliographic Details
Main Authors: Zheng, Lian-Shun, Kaneko, Naoko, Sawamoto, Kazunobu
Format: Online
Language:English
Published: Frontiers Media S.A. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309184/