Biosynthesis
of Versipelostatin: Identification of
an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization
of Spirotetronate-Containing Polyketides

Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides

Bibliographic Details
Main Authors:	Hashimoto, Takuya, Hashimoto, Junko, Teruya, Kuniko, Hirano, Takashi, Shin-ya, Kazuo, Ikeda, Haruo, Liu, Hung-wen, Nishiyama, Makoto, Kuzuyama, Tomohisa
Format:	Online
Language:	English
Published:	American Chemical Society 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308742/

Similar Items

Spirotetronate Polyketides as Leads in Drug Discovery
by: Lacoske, Michelle H., et al.
Published: (2014)

Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis
by: KUZUYAMA, Tomohisa, et al.
Published: (2012)

Recent developments in gold-catalyzed cycloaddition reactions
by: López, Fernando, et al.
Published: (2011)

Gold(I)-catalyzed enantioselective cycloaddition reactions
by: López, Fernando, et al.
Published: (2013)

Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides
by: Zhang, Chi, et al.
Published: (2014)

Ni(NHC)]-Catalyzed Cycloaddition of Diynes and Tropone: Apparent Enone Cycloaddition Involving an 8π Insertion
by: Kumar, Puneet, et al.
Published: (2014)

Novel Tryptophan Metabolism by a Potential Gene Cluster That Is Widely Distributed among Actinomycetes*
by: Ozaki, Taro, et al.
Published: (2013)

Iridium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides
by: Tigchelaar, Andrew, et al.
Published: (2012)

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition
by: Berg, Regina, et al.
Published: (2013)

Propargyltrimethylsilanes as Allene Equivalents in Transition Metal-Catalyzed [5 + 2] Cycloadditions
by: Wender, Paul A., et al.
Published: (2014)

Synthesis of Rumphellaone A and Hushinone by a Gold-Catalyzed [2 + 2] Cycloaddition
by: Ranieri, Beatrice, et al.
Published: (2016)

Meeting the Challenge of Intermolecular Gold(I)-Catalyzed Cycloadditions of Alkynes and Allenes
by: Muratore, Michael E, et al.
Published: (2014)

Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition
by: Palchak, Zachary L, et al.
Published: (2015)

Dissecting Anion Effects in Gold(I)-Catalyzed Intermolecular Cycloadditions
by: Homs, Anna, et al.
Published: (2014)

The Structure of SpnF, a Standalone Enzyme that Catalyzes [4+2] Cycloaddition
by: Fage, Christopher D., et al.
Published: (2015)

Dissecting complex polyketide biosynthesis
by: Caffrey, Patrick
Published: (2012)

Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
by: Tang, Yi, et al.
Published: (2004)

An Enzyme-Catalyzed [4+2] Cycloaddition is a Key Step in the Biosynthesis of Spinosyn A
by: Kim, Hak Joong, et al.
Published: (2011)

Reactivity and Chemoselectivity of Allenes in Rh(I)-Catalyzed Intermolecular (5 + 2) Cycloadditions with Vinylcyclopropanes: Allene-Mediated Rhodacycle Formation Can Poison Rh(I)-Catalyzed Cycloadditions
by: Hong, Xin, et al.
Published: (2014)

Identification and Characterization of Bacterial Diterpene Cyclases that Synthesize the Cembrane Skeleton
by: Meguro, Ayuko, et al.
Published: (2013)

Combinatorial polyketide biosynthesis at higher stage
by: Jenke-Kodama, Holger, et al.
Published: (2005)

Engineering Microbes for Plant Polyketide Biosynthesis
by: Lussier, François-Xavier, et al.
Published: (2013)

Artificial human Met agonists based on macrocycle scaffolds
by: Ito, Kenichiro, et al.
Published: (2015)

Macrocyclic gelators
by: Goh, Ching, et al.
Published: (2013)

Anti-Influenza Activity of Marchantins, Macrocyclic Bisbibenzyls Contained in Liverworts
by: Iwai, Yuma, et al.
Published: (2011)

Theoretical studies on cycloaddition reactions
by: Rhyman, Lydia, et al.
Published: (2014)

Cycloadditions of Cyclohexynes and Cyclopentyne
by: Medina, Jose M., et al.
Published: (2014)

Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
by: Hemmerling, Franziska, et al.
Published: (2016)

Steps towards the synthetic biology of polyketide biosynthesis
by: Cummings, Matthew, et al.
Published: (2014)

Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions
by: Kupracz, Lukas, et al.
Published: (2011)

Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization–(2 + 2) cycloaddition
by: Inanaga, Kazato, et al.
Published: (2012)

Thiophene-based donor–acceptor co-oligomers by copper-catalyzed 1,3-dipolar cycloaddition
by: Potratz, Stefanie, et al.
Published: (2012)

Ruthenium-Catalyzed Intramolecular [2+2+2] Cycloaddition and Tandem Cross-Metathesis of Triynes and Enediynes
by: Yuan, Wei, et al.
Published: (2013)

End-labeled amino terminated monotelechelic glycopolymers generated by ROMP and Cu(I)-catalyzed azide–alkyne cycloaddition
by: Okoth, Ronald, et al.
Published: (2013)

Alkyne-Azide Cycloaddition Catalyzed by Silver Chloride and “Abnormal” Silver N-Heterocyclic Carbene Complex
by: Ortega-Arizmendi, Aldo I., et al.
Published: (2013)

Enantioselective One-Pot Synthesis of α-Amino Esters by a Phosphine-Catalyzed [3+2]-Cycloaddition Reaction
by: Steurer, Marianne, et al.
Published: (2012)

Synthetic scope and DFT analysis of the chiral binap–gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes
by: Martín-Rodríguez, María, et al.
Published: (2013)

Site-Specific Bioconjugation of a Murine Dihydrofolate Reductase Enzyme by Copper(I)-Catalyzed Azide-Alkyne Cycloaddition with Retained Activity
by: Lim, Sung In, et al.
Published: (2014)

Non-Precious Metals Catalyze Formal [4 + 2] Cycloaddition Reactions of 1,2-Diazines and Siloxyalkynes under Ambient Conditions
by: Sumaria, Chintan S., et al.
Published: (2014)

New Initiation Modes for Directed Carbonylative C–C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Aminomethylcyclopropanes
by: Wang, Gang-Wei, et al.
Published: (2016)