Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
Bacterial aromatic polyketides such as tetracycline and doxorubicin are a medicinally important class of natural products produced as secondary metabolites by actinomyces bacteria. Their backbones are derived from malonyl-CoA units by polyketide synthases (PKSs). The nascent polyketide chain is synt...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340942/ |