Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

The tumor suppressor, p53, plays an essential role in the cellular response to stress through regulating the expression of genes involved in cell cycle arrest, apoptosis and autophagy. Here, we used a cell-based reporter system for the detection of p53 response transcription to identify the marine s...

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Bibliographic Details
Main Authors: Lee, Hyun-Young, Chung, Kyu Jin, Hwang, In Hyun, Gwak, Jungsuk, Park, Seoyoung, Ju, Bong Gun, Yun, Eunju, Kim, Dong-Eun, Chung, Young-Hwa, Na, MinKyun, Song, Gyu-Yong, Oh, Sangtaek
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306951/

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