Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells

Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells

The Wnt/β-catenin signaling pathway is known to play critical roles in a wide range of cellular processes: cell proliferation, differentiation, migration and embryonic development. Importantly, dysregulation of this pathway is tightly associated with pathogenesis in most human cancers. Ther...

Full description

Bibliographic Details
Main Authors: Hyun Bong Park, Nguyen Quoc Tuan, Joonseok Oh, Younglim Son, Mark T. Hamann, Robert Stone, Michelle Kelly, Sangtaek Oh, MinKyun Na
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Marine Drugs
Subjects:
natural products
marine sponge
sesterterpenoid
steroid
colorectal cancer
Wnt
β-catenin
Alaska
Online Access:http://www.mdpi.com/1660-3397/16/9/297

Internet

http://www.mdpi.com/1660-3397/16/9/297

Similar Items