JF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib
Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA nick sensor involved in the base excision repair (BER) pathway. Olaparib, a PARP inhibitor, has demonstrated antitumor activity in homologous recombination (HR)-deficient cancers. To extend this specific therapy to other types of carcinomas, a panel of...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
D.A. Spandidos
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301471/ |