The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin

Recent preclinical evidence has suggested that Ewing Sarcoma (ES) bearing EWSR1-ETS fusions could be particularly sensitive to PARP inhibitors (PARPinh) in combination with DNA damage repair (DDR) agents. Trabectedin is an antitumoral agent that modulates EWSR1-FLI1 transcriptional functions, causin...

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Bibliographic Details
Main Authors: Ordóñez, José Luis, Amaral, Ana Teresa, Carcaboso, Angel M., Herrero-Martín, David, García-Macías, María del Carmen, Sevillano, Vicky, Alonso, Diego, Pascual-Pasto, Guillem, San-Segundo, Laura, Vila-Ubach, Monica, Rodrigues, Telmo, Fraile, Susana, Teodosio, Cristina, Mayo-Iscar, Agustín, Aracil, Miguel, Galmarini, Carlos María, Tirado, Oscar M., Mora, Jaume, de Álava, Enrique
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662461/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662461/

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