Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences throughout Evolutionary History

Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences throughout Evolutionary History

Local protein interactions (“molecular context” effects) dictate amino acid replacements and can be described in terms of site-specific, energetic preferences for any different amino acid. It has been recently debated whether these preferences remain approximately constant during evolution or whethe...

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Bibliographic Details
Main Authors: Risso, Valeria A., Manssour-Triedo, Fadia, Delgado-Delgado, Asunción, Arco, Rocio, Barroso-delJesus, Alicia, Ingles-Prieto, Alvaro, Godoy-Ruiz, Raquel, Gavira, Jose A., Gaucher, Eric A., Ibarra-Molero, Beatriz, Sanchez-Ruiz, Jose M.
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298172/

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