The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

The mitochondrial permeability transition (PT) – an abrupt increase permeability of the inner membrane to solutes – is a causative event in ischemia–reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT is due to opening of the PT pore (PTP), a high conductan...

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Bibliographic Details
Main Authors: Bernardi, Paolo, Di Lisa, Fabio
Format: Online
Language:English
Published: Academic Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294587/